夏枯草口服液联合吲哚美辛治疗老年亚急性甲状腺炎的临床观察

Clinical Observation of Prunella vulgaris oral solution Combined with Indomethacin in the Treatment of Elderly Subacute Thyroiditis

目的:观察夏枯草口服液联合吲哚美辛治疗老年亚急性甲状腺炎的临床疗效和安全性。方法:48例老年亚急性甲状腺炎患者按随机数字表法均分为观察组和对照组。对照组患者给予吲哚美辛胶囊50 mg,bid;观察组患者在对照组治疗的基础上给予夏枯草口服液10 ml,bid。两组患者疗程均为4周。观察两组患者的临床疗效,并记录肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、转化生长因子(TGF)-β1、胰岛素样生长因子(IGF)-1的变化及不良反应发生情况。结果:观察组患者总有效率显著高于对照组患者,两组比较差异有统计学意义(P<0.05)。两组患者治疗前各指标比较差异无统计学意义(P>0.05);治疗后,两组患者的TNF-α、hs-CRP和TGF-β1均显著低于同组治疗前,且观察组显著低于对照组,而IGF-1显著高于同组治疗前,且观察组显著高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:夏枯草口服液联合吲哚美辛治疗老年亚急性甲状腺炎患者疗效显著,安全性较好。

OBJECTIVE： To observe clinical efficacy and safety of Prunella vulgar＆ oral solution combined with indomethacin in the treatment of elderly subacute thyroiditis. METHODS ： 48 cases of elderly subacute thyroiditis were randomly divided into observation group and control group. Control group was given Indomethacin capsule 50 mg, bid; observation group was additionally given P. vulgaris oral solution 10 ml, bid. Treatment course of 2 groups lasted for 4 weeks. Clinical efficacies of 2 groups were observed; the changes of TNF-α, hs-CRP, IGF-1 and TGF-β1 and ADR were observed in the two groups. RESULTS： Total effective rate of observation group was higher than that of control group; there was statistical significance （P〈0.05）. There was no statistical significance in each index between 2 groups before treatment （P〉0.05）. After treatment, the expressions of TNF-α, hs-CRP and TGF-β1 in 2 groups were significantly lower than before; those of observation group were lower than those of control group. The expression of IGF-1 was higher than before, and that of observation group was significantly higher than that of control group; there was statistical significance （P〈0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Prunella vulgaris oral solution combined with indomethacin is effective and safe in the treatment of elderly subacute thyroiditis.