摘要
目的:观察盐酸纳美芬治疗急性酒精中毒昏迷患者的临床疗效和安全性。方法:90例急性酒精中毒昏迷患者按随机数字表法均分为观察组和对照组。对照组患者给予盐酸纳洛酮0.8 mg加入0.9%氯化钠注射液20 ml中以1 mg/min的速度静脉推注后,再给予盐酸纳洛酮0.8 mg加入0.9%氯化钠注射液250 ml中静脉滴注;观察组患者给予盐酸纳美芬0.2 mg加入0.9%氯化钠注射液10 ml中以1 mg/min的速度静脉推注后,再给予常规补液1 500 ml静脉滴注。观察两组患者治疗1、2、3 h后临床疗效,观察治疗前后呼吸、心率、血压变化,记录清醒时间、出院时间及不良反应发生情况。结果:观察组患者治疗1、2、3 h后总有效率均显著高于对照组患者,清醒时间和出院时间均显著短于对照组患者,两组比较差异均有统计学意义(P<0.05)。治疗期间患者的呼吸、心率、血压均无明显变化,且均未见其他明显不良反应发生。结论:盐酸纳美芬治疗急性酒精中毒昏迷患者疗效显著,安全性较好。
OBJECTIVE: To observe clinical efficacy and safety of Nalmefene hydrochloride in the treatment of acute alcohol toxicity coma. METHODS: 90 cases of acute alcohol toxicity coma were randomly divided into observation group and control group. Control group was given naloxone hydrochloride 0.8 mg added into 0.9% Sodium chloride injection 20 ml at 1 mg/min, and then received naloxone hydrochloride 0.8 mg added into 0.9% Sodium chloride injection 250 ml intravenously. Observation group was given Nalmefene hydrochloride 0.2 mg added into 0.9% Sodium chloride injection 10 ml at 1 mg/min, and then received conventional rehydration therapy 1 500 ml intravenously. Clinical efficacy of 2 groups was observed in 2 groups 1 h, 2 hand 3 h after treatment, and the changes of respiration, heart rate and blood pressure were recorded before and after treatment, and awake time, discharge time and ADR were recorded in 2 groups. RESULTS: 1 h, 2 h and 3 h after treatment, total effective rate of observation group was significantly higher than that of control group, and awake time and discharge time of observation group were significantly lower than those of control group; there was statistical significance (P〈0.05). There was no obvious change in respiratory, heart rate and blood pressure, and no other obvious ADR was found during treatment. CONCLUSIONS: Nalmefene hydrochloride is effective and safe in the treatment of acute alcohol toxicity coma.
出处
《中国药房》
CAS
CSCD
2014年第12期1103-1105,共3页
China Pharmacy
关键词
盐酸纳美芬
急性酒精中毒昏迷
盐酸纳洛酮
Nalmefene hydrochloride
Acute alcohol toxicity coma
Naloxone hydrochloride