摘要
目的:考察盐酸曲马多注射液与盐酸甲氧氯普胺注射液在静脉镇痛泵中的配伍稳定性。方法:在室温条件下,观察与测定盐酸曲马多注射液与盐酸甲氧氯普胺注射液在静脉镇痛泵中配伍后的外观、不溶性微粒及pH值变化,并用高效液相色谱法测定配伍液中二者的含量变化。结果:室温72 h内,盐酸曲马多与盐酸甲氧氯普胺在静脉镇痛泵(0.9%氯化钠注射液)中混合后的外观、pH、不溶性微粒、含量均无明显变化。结论:在室温条件下,盐酸曲马多注射液与盐酸甲氧氯普胺注射液在静脉镇痛泵中混合后72 h内均保持稳定。
Objective: To study the stability of tramadol hydrochloride injection combined with metoclopramide hydrochloride injection in patient-controlled analgesia (PCA) pumps. Methods: The changes in appearance, particles and pH value of the mixture of the two injections in 0.9% sodium chloride injection within 72 hours at ambient temperature were observed. The concentrations of the mixture of the two injections in 0.9% sodium chloride injection were determined by HPLC within 72 hours. Results : There were no significant changes in the appearance, particles, pH values and contents of both drugs in 0.9% sodium chloride injection within 72 hours at room temperature. Conclusions: The mixture of tramadol hydrochloride combined with metoclopramide hydrochloride is stable within 72 hours under room temperature in PCA pumps.
出处
《儿科药学杂志》
CAS
2014年第3期35-38,共4页
Journal of Pediatric Pharmacy