调强放疗联合腔内后装放疗治疗晚期宫颈癌的临床研究

Clinical research on intensity modulated radiation therapy combined with afterloading radiotherapy for the treatment of advanced cervical cancer

目的探讨调强放疗联合腔内后装放疗治疗晚期宫颈癌的临床效果。方法选取我院收治的晚期宫颈癌患者48例，随机均分为对照组和实验组，对照组行常规放疗联合腔内后装放疗治疗，实验组行调强放疗（IMRT）联合腔内后装放疗治疗。观察比较两组患者放疗疗效及骨髓抑制、放射性膀胱炎、放射性直肠炎、放射性皮炎等不良反应发生率。结果实验组患者放疗总缓解率为91．7％（22／24），显著高于对照组的66．7％（16／24）（P〈0．05）。实验组患者骨髓抑制、放射性膀胱炎、放射性直肠炎等并发症发生率分别为29．2％，33．3％，0．0％，均显著低于对照组患者（P〈0．05）。实验组患者放射性皮炎发生率为O．0％，对照组为16．7％，组间比较差异无统计学意义（P〉0．05）。结论调强放疗联合腔内后装放疗治疗晚期宫颈癌临床疗效确切，能有效减少并发症的发生，值得广泛推广使用。

Objective To investigate the clinical effect of intensity modulated radiation therapy （IMRT） combined with afterloading radiotherapy for the treatment of advanced cervical cancer. Methods 48 patients with advanced cervical cancer were randomly divided into control group （treated with conventional radiotherapy） and experimental group （treated with IMRT combined with afterloading radiotherapy）. The radiotherapy effect and incidence of complications of two groups were compared. Results The total response rate of experimental group was 91.7%, which was significantly higher than 66.7% of control group （P 〈 0.05）. The incidence of complications of experimental group was lower than that of control group. Conclusion IMRTcombined with afterloading radiotherapy is effective for advanced cervical cancer. It is worthy of wide use and promotion.