20例胃肠间质瘤的诊治

Diagnosis and treatment of 20 cases of gastrointestinal stromal tumors

目的：探讨胃肠道间质瘤（GIST）的临床特征、诊断及治疗方法。方法：回顾性分析我院2008年1月-2013年7月经手术切除病理报告确诊的20例GIST的临床资料。结果：全组无手术死亡病例，术后所有患者获得随访，随访时间1个月~5.5年，平均3年。在随访患者中，复发率为15%，复发时间为手术切除后2~19个月（平均9.5个月），复发转移部位为腹腔、肝脏和肺，无死亡病例。结论：GIST是一种具有恶变潜能的肿瘤，早期缺乏特异性症状及体征，术前确诊率低，主要依靠病理及免疫组化结果确诊，目前仍以手术治疗为主，放化疗效果较差，靶向治疗效果较好。

Objective： To study the clinical features, diagnosis and treatment of gastrointestinal stromal tumor （GIST）. Methods：Clinical data on 20 patients with GIST conifrmed by postoperative pathology with operation excision were retrospectively analyzed in our hospital from January 2008 to July 2013. Results：There was no death case of operation. All patients were followed up for 1 month to 5.5 years （average 3 years）. In the patients with follow-up, the recurrence rate was 15%, which usually occurred in 2 to 19 months after operation （average 9.5）, and metastatic sites of recurrence were at abdominal cavity parts, liver and lung. However, there was no report of death case. Conclusion：Gastrointestinal stromal tumor is a kind of malignant tumor and speciifc symptoms and signs are lacked in its early period. Preoperative diagnosis rate is low, which mainly depends on the pathological and immunohistochemical results to conifrm. GIST is mainly treated with operation at present and radiotherapy and chemotherapy are less effective. However, effect of targeting therapy is good.