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血清脂联素及瘦素检测在非酒精性脂肪肝患者中的研究

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摘要 目的探讨血清脂联素、瘦素与非酒精性脂肪肝(NAFLD)患者肝纤维化指标之间的关系。方法分为NAFLD组94例和健康对照组36例,用酶联免疫吸附法检测血清中脂联素、瘦素、Ⅲ型前胶原(PCⅢ)、透明质酸(HA)、Ⅳ型胶原(PCⅣ)、层黏蛋白(LN)的浓度。结果 NAFLD组的瘦素PCⅢ、HA、PCⅣ、LN显著高于对照组(P<0.05),NAFLD组的脂联素水平显著低于对照组(P<0.05),瘦素水平明显高于对照组(P<0.05)。血清脂联素与肝纤维化指标PCⅢ、PCⅣ、HA和LN呈负相关(P<0.05),瘦素与肝纤维化指标PCⅢ、PCⅣ、HA和LN呈正相关(P<0.05)。结论脂联素、瘦素与NAFLD患者肝纤维化相关。
作者 胡燕梅 季伟 郭锐芳 武婷
机构地区 宁夏人民医院
出处 《宁夏医学杂志》 CAS 2014年第2期151-152,共2页 Ningxia Medical Journal
关键词 非酒精性脂肪肝 脂联素 瘦素
分类号 R587.1 [医药卫生—内分泌]
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参考文献8

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宁夏医学杂志
2014年 第2期

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