原发性肝癌肝动脉热化疗栓塞后患者T细胞亚群及sIL-2R的改变

Changes of Soluble Interleukin 2 Receptor and T Lymphocytes Subsets in Patients with PHC after Thermochemoembolotherapy

目的 研究肝癌患者肝动脉热化疗栓塞前后 T细胞亚群及 s IL - 2 R的变化及其临床意义。方法 采用免疫荧光染色法及双抗体夹心法 ,检测 30例原发性肝癌患者治疗前后的 T细胞亚群及 s IL- 2 R的改变 ,并与健康对照组比较分析。结果 肝癌组治疗前 Th降低 ,Ts和 s IL- 2 R增高 ,与对照组比较有显著差异 ,P<0 .0 1 ,治疗后 Th升高 ,Ts和 s IL- 2 R降低 ,治疗前后比较有显著差异 P<0 .0 1。结论 检测肝癌患者 T细胞亚群 ,s IL- 2 R的情况 ,有助了解病人的免疫状况 ,对判断病人预后 ,指导综合治疗有一定价值。热化疗栓塞的疗效优于文献报道的单纯化疗栓塞。

Objective To observe the changes of sIL\|2R and T lymphocytes subsets in patients with PHC before and after thermochemoembolotherapy and evaluate their clinical significance.Methods Immune fluorescent assay and sandwich ELISA were used to measure the immune state of 30 patients with PHC before and after thermochemoembolotherapy and compared them with that of health comtrols.Results In patients with PHC,Th was lower while Ts and sIL\|2R were higher than that of health controls (P< 0.01 ).After therapy,Th elevated while Ts and sIL\|2R declined(P<0.01).Conclusion Measuring sIL\|2R and T lymphocytes subsets is helpful to know the immune state and has significance in directing therapy and judging prognosis.To patients with PHC,the method of thermochemoembolotherapy is superior to that of simplex chemoembolotherapy from medical document.