口腔粘膜原发性恶性黑色素瘤预后因素探讨

Prognostic Factors in Primary Malignant Melanoma of the Oral Mucosa

目的 探讨影响口腔粘膜原发性恶性黑色素瘤预后的因素。方法 回顾分析 35例患者的临床及病理资料。结果 全组总的 5年生存率 2 8.6%。其中临床 ～ 期与 ～ 期分别为45%、6.7% (P<0 .0 1 )。雀斑样型、浅表扩散型与结节型分别为 38.9%、1 4.3% (P<0 .0 1 ) ,病变局限于上皮层者与侵及粘膜下层者分别为 50 %、1 9.1 % (P<0 .0 1 )。手术加化疗组 5年生存率 35.7% ,单纯化疗组均于 5年内死亡。结论 口腔粘膜原发性恶性黑色素瘤的预后与临床分期、病理类型、病变侵袭深度及治疗方式有关。

Objective To study the prognostic factors in malignant melanoma of the oral mucosa.Methods The clinical and pathological data of 35 cases were analysed retrospectively.Results The five\|year survival rate was 45% in stage Ⅰ～Ⅱ and 6.7% in stage Ⅲ～Ⅳ(P<0.01);38.9% in the non\|nodular melanoma and 14.3% in the nodular melanoma(P<0.01);50% in those withinepithelium and 19.1% in those infringed submucosa(P<0.01);66.7% in the positive of lymphatic metastasis and 22.2% in the negative(P<0.01).Conclusion The prognosis of oral mucosa related with tumor stage,tumor type,depth of invasion and the treatment.