米非司酮防治人工流产术后残留临床探讨

Clinical Investigation of Mifepristone in the Treatment of Abortive Remnants of Incomplete Abortion

目的:探讨米非司酮防治早孕人流负压吸引术后残留的有效性及安全性。方法:426例流产后妇女,B超和血β-人绒毛膜促性腺激素(HCG)确诊为人流负压吸引术后残留,随机分为两组,218例常规负压吸宫组(对照组),208例常规负压吸宫术后当天开始口服米非司酮50mg×14d(米非司酮组),比较两组临床症状、B超和血β-HCG监测的疗效及安全性。结果:人流术后行再次刮宫术6例,其中对照组5例(2.19%),米非司酮组1例(0.48%),组间差异有统计学意义(P<0.01);米非司酮治疗组用药2周后阴道流血停止时间、转经时间、血β-HCG和B超明显好于对照组,差异有统计学意义(P<0.01)。结论:应用米非司酮防治人工流产术后残留有效,术后给予米非司酮口服可预防人工流产不全。

Objective：To investigate the efficacy and safety of mifepristone treating abortive remnants of incom- plete abortion.Methods：A total of 426 women undergoing post-abortion treatment who were diagnosed as abortive remnants by ultrasound and blood of human chorionie gonadotrophin （ β-HCG） were divided randomly into 2 groups： control group（n=218） with routine vacuum aspiration, mifepristone group（n =208）, which took oral mifepristone 50mg /d × 14 d. The efficacy and safety of two groups were evaluated by clinical observations,uhrasonie and blood level of β -HCG checks.Results：There were 5 eases with incomplete abortion accepted curettage again, and 5 eases（2.19%） in control group, 1 case（0.48%） in mifepristone group（P〈0.01）. Conelusion：Mifepristone is effective in the treatment of incomplete abortion, which takes as a drug for prevention of incomplete abortion.