冠心病与免疫反应关系的临床研究

Clinical study on relationship between immunoreaction and coronary artery disease

目的 探讨免疫反应与冠心病 (CAD)之间的关系。方法 将 42例经冠状动脉 (冠脉 )造影证实其冠脉有异常改变的CAD患者和 2 0例经冠脉造影证实其冠脉无异常改变的非冠心病患者 (NCAD)作为观察对象 ;CAD患者包括稳定型心绞痛 (SAP) 17例、不稳定型心绞痛 (UAP) 12例和急性心肌梗死 (AMI) 13例 ,并测定其下述指标 :免疫球蛋白IgG、IgA、IgM和补体C3、C4 。结果 AMI组的IgG、IgA、C3 和C4 水平及UAP组的IgG水平明显高于SAP和NCAD组 ;同时SAP和NCAD组之间的IgG、IgA、C3 和C4 水平及四组间的IgM水平比较差异无显著性。 结论 IgG、IgA、C3 和C4 水平的增高与冠心病的发生密切相关。

Objective To explore the relationship between immunoreaction and coronary artery disease (CAD).Methods The levels of immunoglobulin (IgG, IgA, IgM) and complement (C 3 and C 4) were measured in 42 patients with CAD, confirmed by abnormal angiography and 20 patients with normal angiography, served as control(NCAD). 42 CAD were subdivided into 3 groups:17 cases of stable angina pectoris(SAP),12 cases of unstable angina pectoris (UAP) and 13 case of acute myocardial infarction (AMI).Results The levels of IgG,IgA,C 3 and C 4 in AMI group and the level of IgG in UAP group were significantly higher than those in SAP and NCAD groups.While the levels of lgG,IgA, C 3 and C 4 between SAP and NCAD groups ,the levels of IgM in all groups showed no significant difference.Conclusion The incidence of CAD was correlated with the elevation of lgG, IgA, C 3 and C 4.