葡甲胺环腺苷酸对充血性心力衰竭患者心功能的影响

Effect of meglumini cyclo-adenylate on cardiac function in patients with congestive heart failure

目的 观察葡甲胺环腺苷酸 (MCA)对心力衰竭患者 (CHF)心功能的影响 ,探讨其作用机理。方法 CHF患者 12例 ,心功能Ⅲ～Ⅳ级 ,给予MCA 90mg稀释后静点 ,用漂浮导管监测给药前及给药后 3h的心功能参数变化。结果 MCA降低肺动脉平均压 [(39.0 0± 12 .2 4)vs (35 .17± 10 .6 9)mmHg]和肺动脉镶嵌压 [(2 5 .17± 7.76 )vs (2 1.0 8± 6 .82 )mmHg] ,增加心指数 [(2 .6 5± 0 .6 6 )vs (2 .81± 0 .5 2 )L/m /m2 ]和心搏量 [(4.6 3± 1.33)vs (4.92± 1.39)L/m] ,并减少体循环阻力 [(2 14 1.5 8± 792 .5 1)vs (180 7.83± 5 84.2 1)dyness·s·cm 5]和肺循环阻力 [(75 0 .2 7± 36 8.12 )vs (6 0 1.0 0± 5 84.2 1)dyness·s·cm 5] ,使右房压降低 [(11.17± 3 .91)vs (9.33± 3 .5 5 )mmHg]。 结论 MCA可以改善心功能 ,降低循环阻力和后负荷。

Objective To evaluate the effects of meglumini cyclo adenylate(MCA) on cardiac function in patients with congestive heart failure(CHF).Methods The cardiac catheterization was performed in 12 patients with CHF, and the parameters of heart function were investigated before and after intravenous 90 mg MCA drip.Results After intravenous MCA drip, the mean pressure of pulmonary artery,diastolic pressure of pulmonary artery, resistance of systematic circulation, resistance pulmonary circulation and pressure of right atrium decresed. The cardiac index and output increased.Conclusion MCA improves cardiac function by reduction of circulative resistance and afterload, hence it is a useful agent for CHF.