肝硬化患者血小板活化状态与内皮细胞损伤测定的临床意义

Clinical significance of blood platelet activation and endothelial cell injury in cirrhosis

目的 探讨血小板活化状态与内皮细胞损伤在肝硬化病理生理及其临床意义。方法 对 5 8例肝炎后肝硬化患者与 30名正常对照者采用双抗体夹心放射免疫法测定血浆血小板α 颗粒膜蛋白 (GMP 14 0 ) ,放射免疫法测定内皮素 1(ET 1)含量。结果 肝硬化患者血浆GMP 14 0、ET 1水平比对照组有明显的增高 (P <0 .0 1) ,并且随着肝硬化Child分级程度的加重 ,升高越来越明显。结论 肝硬化患者血浆GMP 14 0、ET 1的升高可反映体内血小板活化及血管内皮细胞损伤的程度 。

Objective To study the pathophysiologic and clinical significance of activated blood platelets and endothelial cell injury in cirrhosis.Methods The Plasma GMP 140 and ET 1 levels were measured in 58 cases of cirrhosis and 30 normal subjects by radioimmunoassay.Results The levels of plasma GMP 140 and ET 1 significantly increased in cirrhosis in comparison with normal subjects(P<0.01).Plasma GMP 140 and ET 1 levels were correlated with severity of cirrhosis and Child pugh score stage.Conclusion Increase of GMP 140 and ET 1 in cirrhosis may reflect the degree of blood platelets activation and hepatic vascular endothelial injury. They play important role in microcirculation disorganization.