摘要
目的探讨心肌缺血再灌注损伤与Bcl-2家族蛋白调控自噬的关系,阐述Bcl-2家族蛋白通过调控自噬而影响心肌缺血再灌注损伤的作用机制。方法查阅近年来国内外心肌缺血再灌注损伤相关的Bcl-2家族蛋白调控自噬的文献,在对文献进行分析和整理的基础上进行综述。结果与结论在缺血早期,心肌细胞发生适当程度的自噬能够减轻缺血导致的心肌损伤,而在再灌注期,过度激活的自噬能加重心肌细胞的损伤;Bcl-2家族蛋白是自噬的重要调节因子,与自噬信号通路中其他相关因子相互作用,在心肌缺血与再灌注损伤的两个不同时期发挥重要的作用。
OBJECTIVE Investigate the relationship between myocardial ischemia-reperfusion injury and Bcl-2 family proteins regulating autophagy were searched, and elaborated the mechanism of Bcl-2 family proteins affecting myocardial ischemia-reperfusion injury by regulating autophagy. METHODS The literatures which related to myocardial ischemia-reperfusion injury and Bcl-2 family proteins regulating autophagy were searched. The review is finished by analyzing and organizing the literatures. RESULTS AND CONCLUSION In early ischemia, appropriate autophagy of myocardial cells can reduce the degree of ischemia-induced myocardial injury, however, in the reperfusion period, excessive activation of autophagy can aggravate myocardial cell injury. Bcl-2 family proteins are important regulation factors of autophagy, it can play an important role by interacting with other relevant factors contained in autoph- agy pathway during the two different periods of myocardial ischemia and reperfusion injury.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2014年第5期353-356,共4页
Chinese Pharmaceutical Journal
基金
“重大新药创制”科技重大专项(2013ZX09103-001-008,2012ZX09103-101-078)
国际科技合作专项项目(2011DFR31240)
