多发性淋巴瘤性息肉病型套细胞淋巴瘤1例报告并文献复习

Multiple lymphomatous polyposis type mantle cell lymphoma:a report of one case and literatures review

目的:探讨多发性淋巴瘤性息肉病型套细胞淋巴瘤的诊断、鉴别诊断及治疗方案。方法:回顾1例多发性淋巴瘤性息肉病型套细胞淋巴瘤临床及病理表现,对相关文献进行复习。结果:回肠末段多发性息肉瘤细胞累及黏膜固有层及黏膜下层,破坏淋巴滤泡;CD20、CD79α、cyclinD1、CD5等抗原表达阳性。结论:多发性淋巴瘤性息肉病型是一种罕见的胃肠道非霍奇金淋巴瘤,多为套细胞性淋巴瘤,具有特殊的免疫表型,其恶性程度高,治疗难度大,以综合治疗为主,预后差。

Objective：To investigate the diagnosis, differential diagnosis and treatment of mantle cell lymphomas（MCL） presenting as multiple lymphomatous polyposis（MLP）. Methods：The clinical manifestation and pathological characteristics of one case with MLP/ MCL were retrospectively analyzed, and the literatures were reviewed. Results： Multiple polyps in terminal ileum, tumor cells involving mucosa lamina propria and submucosa and lymphoid follicle damage were found. The positive expresses of CD20, CD79α, cyclinD1 and CD5 in tumor cells were detected. Conclusions： MLP is a particularly rare clinical type of non-Hodgkin lymphoma,which is classified as MCL, showing special immunophenotype, it is high malignancy, difficult to treat and poor prognosis.