Caspase-3在妊娠期高血压疾病胎盘组织中的表达及其意义

Expression and clinical significance of Caspase-3 in placental tissues of patients with hypertension disorder complicating pregnancy

目的探讨Caspase-3在妊娠期高血压疾病胎盘组织中的表达及临床意义。方法利用免疫组织化学SP法检测正常妊娠者30例(对照组)和妊娠期高血压疾病者30例(实验组)胎盘组织中Caspase-3的表达,探讨Caspase-3与妊娠期高血压疾病的关系。结果 Caspase-3在实验组胎盘组织中明显高表达,与对照组比较有显著差异(t=7.52,P<0.05);Caspase-3阳性表达率随病情加重而显著增高。结论 Caspase-3在妊娠期高血压疾病中高表达,可能上调合体滋养细胞的凋亡而参与妊娠期高血压疾病的发生发展。

Objective To investigate expression and clinical significance of Caspase-3 in placenta of patients with hyperten-sive disorder complicating pregnancy. Methods The expression of Caspase-3 in placenta of 30 normal pregnant women （as con-trols） and 30 pregnant women with hypertensive disorder complicating pregnancy （in study group） were detected by using SP method of immunohistochemistry,and the relationship between expression of Caspase-3 and hypertensive disorder complicating pregnancy was explored. Results The expression level of Caspase-3 in placenta villous of study group was significantly higher than that of control group. Along with aggravation of severity of the disease,the positive expression rate of Caspase-3 was in-creased significantly. Conclusion The increased expression of Caspase-3 in placenta of patients with hypertensive disorder com-plicating pregnancy may be involved in pathogenesis of the disease by increasing the apoptosis of syncytiotrophoblast.