地佐辛与吗啡在重症医学科镇痛、镇静的疗效比较

The clinical comparative analysis of Dezocine and Morphine in the department of critical care medicine

目的比较地佐辛、吗啡在重症医学科镇痛、镇静的疗效。方法将60例重症医学科患者随机均分为地佐辛组、吗啡组。地佐辛组:地佐辛1.25mg/h静脉持续泵入;吗啡组:吗啡2mg/h静脉持续泵入。记录并比较24h、48h、72h的疼痛视觉模拟评分(VAS评分)以及不良反应发生情况。结果两组疼痛VAS评分的差异无统计学意义(P>0.05)。地佐辛组患者不良反应发生率为16.7%,显著低于吗啡组的43.3%,差异有统计学意义(P<0.05)。结论地佐辛镇痛效果与吗啡相似,但不良反应更少。

Objective To probe into the clinical comparative analysis of Dezocine and Morphine treatment of analgesia and se-dation in the department of critical care medicine. Methods Selected 60 patients in ICU.The patients were divided into Dezocine group and Morphine group randomly. dezocine group with venous continuously pumping dezocine （1.25mg/h）;Morphine group with venous continuously pumping morphine（2mg/h）;Record and compare the 24h,48h,72h pain visual analogue scale （VAS score） and adverse reactions. Results Two groups of pain VAS score were no statistically significant difference （P〉0.05）. Compared with Mor-phine group adverse reaction rate was 43.3%,the patients in Dezocine group the adverse reaction rate was 16.7% reduce signifi-cantly,there were significant difference（P〈0.05）. Conclusion Compared with Morphine,Dezocine has effective effect to control the pain of patients and the incidence of adverse reactions was reduced relatively.