早期糖尿病肾病痰湿证与生长转化因子、内皮素等相关性的研究

Study on Relationship between Phlegm-damp Syndrome of the Early-stage DN Patients and TGF-β、ET

目的从血糖、血压、血脂,以及血浆生长转化因子(TGF-β)、内皮素(ET)这4个角度,观察早期糖尿病肾病(DN)痰湿证与非痰湿证患者、糖尿病(DM)无血管病变患者之间的区别,研究这些因素与中医痰湿辨证的相关性。方法选择早期DN患者95例,其中痰湿证组49人,非痰湿证组46人,另设50例DM患者为对照组。对以上各组的高血压分级、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、甘油三酯(TG)、胆固醇(TC),以及血浆TGF-β、ET水平进行比较。结果相较非痰湿证DN患者,高血压、血脂紊乱的现象在痰湿证患者中更普遍;血浆ET水平明显增高,差异具有显著统计学意义(P<0.01)。结论高血压、血脂紊乱可能与中医痰湿辨证有关;ET水平有可能成为判断DN痰湿证的理想指标。

Objective To study the difference between the DM patients and the early-stage DN patients and the difference between the Phlegm-damp syndrome and non-Phlegm-damp syndrome patients, 4 factors including blood glucose,blood pressure, blood lipid,blood plasma TGF-β,ET were measured. Methods 95 early-stage DN patients were involved：49 patients were involved in the Phlegm-damp syndrome group, while the other 46 patients were involved in the non-Phlegm-damp syndrome group. Another 50 diabetes patients without vascular disease were chosen as normal group. We compared the blood pressure,FPG,TG,TC and TGF-β,ET of the above groups. Results Compared with DN non-Phlegm-damp syndrome group, hypertension ,lipid metabolism disorder were more common in the Phlegm-damp syndrome group;the ET level in the DN Phlegm-damp syndrome group was obviously higher than that in the non-Phlegm-damp syndrome group, and the difference was statistically significant （P〈0.01）. Conclusion Hypertension,lipid metabolism disorder may connect with the TCM Phlegm-damp differentiation;The ET level might be a sensitive and ideal factor to differentiate the Phlegm-damp syndrome.