摘要
微卫星DNA是指以少数几个（1～6个）核苷酸为单位串联重复的序列，在真核生物基因组中普遍存在．具有多态性高、呈共显性遗传、操作简单、结果稳定可靠等特点。微卫星突变率通常高于其他类型的遗传标记。微卫星突变率的估算在进化生物学和群体遗传学中具有重要意义。本文对微卫星突变率的估算方法和特点以及在人类、动物和植物中的研究情况进行了概述，对相关问题进行了讨论。
Microsatellites are tandem repeats of short （1-6 bp） units of DNA that occur with high frequency in eukaryotic genomes. They are characterized by abundant polymorphism, co-dominant inheritance, ease of manipulation and reliable results. Microsatellite mutation rate is usually higher than other genetic markers. The estimation of microsatellite mutation rate is very important in evolutionary biology and population genetics. The methods and characteristics of estimation of microsatellite mutation rate and their applications in human, animals and plants were summarized in this paper. At the same time , some related issues were discussed.
出处
《中国畜牧杂志》
CAS
北大核心
2014年第5期87-92,共6页
Chinese Journal of Animal Science
基金
广东省高等学校科技创新重点项目(cxzd1130)
广东省教育部产学研结合项目(2011B090400165)
关键词
微卫星DNA
突变率
系谱分析
突变累积实验
系统发育分析
microsatellite DNA
mutation rate
pedigree analysis
mutation accumulation experiment
phylogenetic analysis
