HBV感染对FibroScan（R）实施受控衰减参数评价脂肪肝影响的研究

Effection of HBV on controlled attenuation parameters using FibroScan（R）

目的 评价HBV感染是否对FibroScan（R）实施受控衰减参数（CAP）有影响.方法 使用FibroScan-502机型对临床诊断非酒精性脂肪性肝病（NAFLD）患者、慢性乙型肝炎患者（CHB）及慢性乙肝合并脂肪肝（CHB合并NAFLD）患者进行肝脏脂肪含量（CAP值）测定.结果 579例CHB患者、124例CHB合并NAFLD患者和624例NAFLD患者FibroScan检查,FibroScan测定的CAP与BMI呈正相关（r=0.46,P=0.004）,而与血清HBV NDA载量、HBsAg载量以及HBeAg阳性与否无关；CHB组的CAP值（218.90 ＆#177;56.40 dB/m）显著低于NAFLD组（290.85＆#177;61.46 dB/m,P=0.00）,也低于CHB合并NAFLD组（284.93＆#177;64.70 dB/m,P=0.00）,而CHB合并NAFLD组的CAP值与NAFLD组间的差异无统计学意义（P=0.55）；血清高HBV DNA载量组的CAP值与低HBV DNA载量组间,高HBsAg载量的CAP值与低HBsAg载量组间,以及HBeAg阳性组的CAP值与HBeAg阴性组间差异均无统计学意义.结论 HBV感染不影响FibroScan测定的CAP值.

Objective To evulate the effection of HBV on controlled attenuation parameters（CAP）measurement of fatty liver using FibroScan（R）.Methods Patients with only non alcohol fatty liverdisease （NAFLD）,only chronic hepatitis B（CHB）and CHB combining with NAFLD （CHB ＋ NAFLD） were complete the CAP measurement with FibroScan-502.Results 579 patients with CHB,624 patients with NAFLD and 124 patients with CHB ＋ NAFLD were recruited.CAP values of CHB was 218.90 ＆#177;56.40 dB/m,significantly lower than that of NAFLD （290.85 ＆#177; 61.46 dB/m,P =0.00） and that of CHB ＋ NAFLD （284.93 ＆#177;64.70 dB/m,P =0.00）.It is no difference between CAP values of CHB ＋ NAFLD and NAFLD （P =0.55）.It is no difference between CAP values of high load of HBVDNA group and the low,high load of HBsAg group and the low,and HBeAg positive group and the negative （P =0.73,0.93,0.55）.Conclusion HBV infection does not effect on CAP values of FibroScan（R）.