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抗酶原颗粒膜糖蛋白2抗体在炎症性肠病中的临床意义 被引量:2

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摘要 炎症性肠病(inflammatory bowel disease,IBD),包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn’s disease,CD),是一种病因尚不十分明确的肠道慢性非特男性炎症性疾病,目前认为其发病与环境、遗传、感染和免疫笔多种因素有关。研究表明,27%~39%的CD患者血清中存在胰腺自身抗体(pancreatic autoantibodies,PAB),而只有才到8%的UC或非IBD患者血清中存在PAB,提示PAB可饿是cD的特异性标志物^[1]。
出处 《中华内科杂志》 CAS CSCD 北大核心 2014年第3期214-215,共2页 Chinese Journal of Internal Medicine
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  • 1Bogdanos DP,Rigopoulou EI,Smyk DS,et al.Diagnostic value,clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn' s disease specific-pancreatic autoantibodies[J].Autoimmun Rev,2011,11:143-148.
  • 2Roggenbuck D,Hausdorf G,Martinez-Gamboa L,et al.Identification of GP2,the major zymogen granule membrane glycoprotein,as the autoantigen of pancreatic antibodies in Crohn's disease[J].Gut,2009,58:1620-1628.
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  • 5Pavlidis P,Romanidou O,Roggenbuck D,et al.Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease[J].Clin Dev Immunol,2012,2012:640835.
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