肺癌诊治水平的进展与提高

Advances and Improvements in the Diagnoses and Treatments of Lung Cancer

肺癌是恶性肿瘤死亡的首要原因。本专题主要针对肺癌流行病学、早期筛查及诊断、以及治疗策略等热点问题进行研究,提出目前肺癌的临床流行病学及病理类型分布的变化,阐述低剂量CT及孤立性结节影像学特点在肺癌早期筛查诊断中的价值,研究晚期脑转移肺癌及肺肉瘤样癌患者的治疗策略,并探索靶向治疗的新靶点。在规范化诊治的基础上,通过基础研究获得新发现并逐步应用于临床,从而提高肺癌高危人群早期筛查的准确率,从分子病理水平对肺癌进行分子分型,充分实现个体化治疗,改善晚期肺癌治疗策略,达到改善患者生存和预后的目的。

Lung cancer is the leading cause of cancer-related death worldwide. The topics of this issue include the changes of lung cancer epidemiology and its histological characteristics, the value of low dose CT in early detection of lung cancer and the image characteristics of solitary pulmonary nodule in early diagnosis of lung cancer, the advances in the therapeutic strategies for lung cancer with brain metastases and pulmonary sarcomatoid carcinoma, and new potential targets of molecular targeted therapy in lung cancer. In order to more effectively improve the survival and prognosis of the patients with lung cancer, it is necessary to strengthen basic research on the molecular pathogenesis of lung cancer, and to translate the advances in basic research into the efforts of exploring the specific and sensitive diagnosis tools for lung cancer, and so increasing the accuracy of early screening and diagnosis, as well as classifying the lung cancer by molecular pathology to achieve individualized therapy.