血流力学信号与肝再生的研究进展

Research progress of hemodynamic signal and liver regener-ation

肝脏再生能力强，外科手术预后与肝再生能力密切相关。肝再生的机制主要包括生化学说和流体力学学说。适度门静脉血流高压灌注是启动肝再生的必要因素。肝动脉缓冲反应、流体切应力的变化、气体信号分子均在肝再生过程中起着重要作用。研究肝再生的血流力学信号机制对肝脏疾病的治疗具有重要意义。

Liver has great ability in regeneration, and liver regeneration is closely related to the prognosis of patients who received liver surgeries. The mechanisms of liver regenera- tion include biochemical theory and hemodynamic theory. Portal perfusion with moderate pressure is an important factor for start- ing liver regeneration. Hepatic artery buffer response, fluid shear stress and gasotransmitter play important roles in the liver regeneration. Learning the mechanisms of hemodynamic signal is of great importance for the treatment of liver diseases.