复聪香液为主治疗血管性痴呆60例疗效观察

Clinical efficacy of Fucongxiang liquid- based therapy in treatment of vascular dementia:a report of 60 cases

目的:观察复聪香液为主治疗血管性痴呆(VD)的临床疗效及作用机制。方法:将120例VD患者随机分为两组各60例,治疗组采用复聪香液结合针刺、穴位热敷及穴位注射治疗,对照组采用阿斯匹林、尼莫地平、都可喜治疗。两组均治疗15d为1个疗程,共治4个疗程,治疗结束后采用简易智力状态检查量表(MMSE)和日常生活能力评定量表(ADL)评定,比较两组治疗前后MMSE和ADL评分,并观察红细胞超氧化物歧化酶(SOD)活性、血浆过氧化脂(LPO)、三酰甘油(TG)、血清胆固醇(TCH)、高密度脂蛋白(HDL)等指标变化。结果:治疗后两组MMSE、ADL评分情况与治疗前比较,差异均有统计学意义(P<0.01);治疗后治疗组MMSE、ADL评分与对照组比较,差异均有统计学意义(P<0.05)。治疗组治疗后SOD、LPO、TG、TCH、HDL等指标较对照组改善更明显(P<0.05)。结论:复聪香液为主治疗血管性痴呆能够改善患者的智力,减轻痴呆程度,改善VD患者SOD、LPO、TG、TCH、HDL等指标。

Objective：To investigate the clinical efficacy and action mechanism of Fucongxiang liquid -based therapy in the treatment of vascular dementia （VD）. Methods：A total of 120 VD patients were randomly divided into treatment group （n = 60） and control group （n =60）. The treatment group received Fucongxiang liquid combined with acupuncture,hot compress at acup0ints,and acupoint injection,while the control group received aspirin, nimodipine, and Duxil. Both groups received four courses of treatment （15 d per course）. After treatment,the outcomes were eval- uated by the Mini -Mental State Examination （MMSE） and Activity of Daily Living Scale （ADL） ,and before -after and between - group comparisons of MMSE and ADL scores were made ; the changes in activity of erythrocyte superox- ide dismutase （SOD）, plasma lipid peroxide （LPO）, triglyceride （TG）, serum total cholesterol （ TCh）, and high - density lipoprotein （HDL） were assessed. Results：After treatment,both groups showed significant changes in MMSE and ADL scores （P 〈0. 01 ） ;there were significant differences in MMSE and ADL scores between the treatment group and control group （P 〈 0. 05 ）. The treatment led to significantly more improvements in SOD, LPO ,TG ,TCh, and HDL in the treatment group than in the control group （P 〈 0. 05 ）. Conclusion ： Fucongxiang liquid - based therapy can im- prove intelligence, reduce dementia, and improve SOD, LPO,TG, TCh, and HDL in VD patients.