Ti-Ta-O涂层的抗凝血性研究

Antithrombus Properties of Ti-Ta-O Coating

利用磁控溅射技术合成了Ti Ta O薄膜涂层。采用体外血小板粘附试验、动态凝血时间测定以及动物体内试片埋植试验等评价方法 ,对涂层的抗凝血特性进行了研究 ;并采用Tauc法研究了涂层的禁带宽度。研究结果表明 ,Ti Ta O薄膜涂层具有良好的抗凝血特性以及禁带宽度为 3.2eV的半导体特性。此外 ,探讨了Ti Ta O涂层的抗凝血机理 ,并提出材料的半导体特性是影响Ti Ta O涂层抗凝血特性的主要原因之一。

Ti Ta O coating was synthesized by magnetron sputtering deposition. Antithrombus property of the coating was evaluated by in vitro clotting time measurement, platelet adhesion and in vivo investigation. All results showed that the coating has attractive blood compatibility. The Ti Ta O coating is of semi conductivity, and the band gap is 3. 2eV. In addition, blood compatibility mechanism is discussed, and it is considered that the semiconductivity of the coating might be significant factor to effect the blood compatibility.