孤啡肽在中枢神经系统内的分布及生理功能

Distribution and physiological function of orphanin FQ(OFQ) in central nervous system

孤啡肽是一种新的内阿片肽 ,在中枢神经系统内均有分布 ,尤其是在下丘脑及边缘系统分布广泛 .孤啡肽有多种生理特性如参与痛觉传递质与调制 ,抑制心血管活动 ,影响运动与行为 ,与情绪反应和记忆有关 ,以及有神经内分泌和免疫功能等 .本文对孤啡肽在中枢神经系统的分布特点及生理功能作了介绍 .

Orphanin FQ(OFQ) is a novel endogenous opioid peptides, it distributes in center nervous system, especially widespread in hypothalamus and linbic system. OFQ have many physiological functions such as nocieption, cardidvascular, locomtion, feeling and learning-memory, neuroendocrine, immune response et al.