食物依赖-运动诱发过敏反应的研究进展

Food-dependent exercise-induced anaphylaxis

食物依赖一运动诱发的过敏反应是食物过敏导致严重过敏反应的一种独特类型，临床较少见，单纯进食致敏食物或运动本身均不会导致其发生，但两者联合则会诱发不同程度的过敏反应，严重时可危及生命。发病机制尚不完全明了，各种假设包括：胃肠道通透性增加、血液的重新分布、阿司匹林的摄入、血液pH值的改变等。治疗上以抗组胺药物、肾上腺素和糖皮质激素等对症治疗为主。

As a unique form of food allergy, food-dependent exercise-induced anaphylaxis （FDEIA） is a rare and potentially life-threatening clinical syndrome. It only occurs in the presence of both ingested sensitizing food and exercise, and either of them alone cannot induce its development. The pathophysiology of FDEIA is not fully understood, and relevant hypotheses include increase in gastrointestinal permeability, redistribution of blood flow, ingestion of aspirin, alteration in plasma pH, and so on. Symptomatic therapy remains the mainstay of treatment for FDEIA, such as anti-histamines, epinephrine and glucocorticoids.