机体微环境对血管平滑肌细胞表型转化调控影响研究概况

Summary of Studies on Effects of Body Microenvironment on Regulation of Phenotypic Modulation in Vascular Smooth Muscle Cells

成熟分化的血管平滑肌细胞(vascular smooth muscle cells,VSMC)保留了在机体的微环境因素诱导下转化表型进而获得迁移、增殖、分泌的能力;因表型转化引起的血管肥大、内膜增厚、斑块等改变是心脑血管疾病发生、发展的病理基础。本文对血管平滑肌细胞表型转化的概念、特点和研究涉及较多的调控因素进行了简述,以期为相关疾病的综合诊断和治疗提供新思路。

The fully matured vascular smooth muscle cells （VSMC） retained remarkable plasticity and reversi- ble changes in phenotype under body microenvironment factors, then abilities of migration, proliferation, and secretion of extracellular matrix components were obtained. These changes could present in response to local microenvironment factors normally to regulate its phenotype. Considered the phenotype switching of VSMC played a key role in the pathologic basis of the occurance and develop of cardio-cerebro-vascular diseases, such as vascular hypertrophy, intimal thickening and plaques. This paper summarized the concepts and char- acters of phenotypic modulation in vascular smooth muscle cells, as well as the relative regulatng factors with them. It was to orovide the new thought for comprehensive diagnosis and therapy of the relaive diseases.