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胶质细胞:帕金森病致病中的两面派 被引量:4

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摘要 帕金森病是一类常见的病因不明的神经退行性疾病,普遍认为是由多种致病因素混合导致,其中由胶质细胞所介导的神经炎症日益受到重视。神经胶质细胞主要包括星形胶质细胞,小胶质细胞和少突胶质细胞,目前的研究主要集中在前两者,生理状态下,这两种胶质细胞协同维护着神经系统的稳态,当受到各种内外刺激而过度活化后,在继续发挥保护作用的同时,又可以通过各自不同的分子机制加重周围神经元的损害。明确具体的分子机制,就可以通过药物靶向干预来充分发挥胶质细胞的保护作用并抑制其损害作用,达到治疗帕金森病的目的。现就这一领域的研究进展进行综述。
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第4期437-439,共3页 Chinese Journal of Cellular and Molecular Immunology
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