传染性软疣58例临床及病理分析

Clinical and pathologic analysis of 58 cases of molluscum contagiosum

目的:分析传染性软疣(Molluscum Contagiosum,MC)的临床病理特点。方法:收集58例MC患者的临床和病理资料进行综合分析。结果:MC发病男女比例约2.9:1,多无自觉症状。皮疹成人多位于下腹部、股内侧和外生殖器部位,而儿童多在面、躯干和四肢。虽然MC为常见皮肤病,本组中发现其临床误诊率为46.6%。组织病理特征为小叶状、内生性生长的结节,角质形成细胞胞质中存在包涵体,即软疣小体,可继发感染或并发表皮囊肿等。结论:MC继发感染或并发表皮囊肿等其他皮肤损害时,临床表现多不典型,组织病理可确诊。

Objective： To analyze the clinical and pathologic features of molluscum contagiosum （MC）. Methods： The clinical and pathologic profiles of 58 patients with MC were collected and analyzed. Results： The ratio of male to female was 2.9 ： 1 in this group of patients. The skin lesions occurred anywhere of the body. In children the lesion was located predominantly on the face, trunk, and extremities. In adults, on the other hand, the skin lesions were often located on the lower abdomen, inner thighs, pubic area, and genitalia. Even though MC was a very common skin disorder, the misdiagnosis rate was 46.6% in our group. The histopathologic features of MC showed lobular endophytic nodules and intracytoplasmic eosinophilie structures termed molluscum bodies in the keratinocytes. Secondary infection and in association with epidermal cyst were found. Conclusion： Correct diagnosis of MC can be easily made based on clinical manifestations for typical cases. However, in the situation of secondary infection or in association with other dermatoses a misdiagnosis may occur. Histopathologie examination can give a correct diagnosis.