非溃疡性消化不良及慢性非萎缩性胃炎幽门螺杆菌感染4年前后比较

Comparison of the Helicobacter pylori infection status and its changing trends during 4 years in non-ulcer dyspepsia and chronic non-atrophic gastritis patients

目的了解成都地区非溃疡性消化不良(NUD)及慢性非萎缩性胃炎(NAG)患者幽门螺杆菌(H.pylori)感染情况及变化趋势。方法纳入经胃镜检查确诊为NUD及NAG患者共2 403例,其中2008年1 042例,2012年1 361例。将NAG患者分为非糜烂性胃炎(NEG)、平坦糜烂性胃炎(FEG)及隆起糜烂性胃炎(REG)三组。所有患者以ASSURE快速血清学方法检测H.pylori感染状态。结果 4年后H.pylori现症感染总体检出率显著下降(35.1%vs 24.8%,P<0.01),在NUD、所有NAG患者及FEG患者中均显著下降(P<0.05)。H.pylori现症感染检出率FEG患者明显高于同期REG、NEG、NUD患者(P<0.05)。REG患者与同期NEG、NUD患者比较,差异无统计学意义(P>0.05)。4年后FEG、REG患者H.pylori既往感染率明显升高(FEG:3.5%vs 10.8%,REG:5.2%vs 12.9%,P<0.05)。结论 2008年至2012年成都地区NUD及NAG患者H.pylori现症感染率显著下降,FEG、REG H.pylori既往感染率明显升高。NAG患者中可能FEG与H.pylori感染关系更为密切。

Objective To study the prevalence and its changing trends of Helicobacter pylori （H. pylori ） infection in the non-ulcer dyspepsia（NUD） and chronic non-atrophic gastritis （NAG） patients in Chengdu. Methods 2 403 NUD and NAG patients diagnosed by endoscopy were collected （1 042 cases in 2008, 1 361 cases in 2012）. The NAG patients were divided into three groups： non-erosive gastritis （NEG） , fiat erosive gastritis （FEG） and raised erosive gastritis （REG）. The seroprevalenee of H. pylori infection was detected by the ASSURER H. pylori Rapid Test. Results The overall prevalence of H. pylori current infection was decreased significantly during the past 4 years （35.1% vs 24.8% ,P 〈0.01 ）. The same findings were obtained in the NUD, the whole NAG and the FEG patients. The H. pylori current infection rate in FEG patients was significantly higher than that of the REG, NEG, NUD patients in the same pe- riods （P 〈 0.05）. There was no significant difference among REG, NEG and NUD patients in the same periods （P 〉 0.05）. The H. pylori previous infection rate was significantly increased in FEG, REG patients during the past 4 years （FEG：3.5% vs 10.8%, REG：5.2% vs 12.9%,P〈0.05）. Conclusion From 2008 to 2012, the prevalence of H. pylori current infection is decreased significantly while the prevalence of the H. pylori previous infection in FEG and REG is increased significantly. In the NAG patients, FEG is related to H. pylori infection more closely than the other types of NAG.