摘要
目的通过观察5-羟色胺(5-HT4)受体激动剂对人消化间期移行性复合运动(MMC)及血浆胃肠激素的影响,探讨5-HT4受体激动剂对MMC的调控作用及其可能的介导因素。方法选取健康志愿者18人并观察给予选择性5-HT4受体激动剂后MMC的变化。并且在给药前后检测MMC不同时期血浆胃动素(MOT)、生长抑素(SS)、NO的浓度。结果健康人给药后MMC周期显著缩短[(87.5+24.2)min vs(60.5±18.4)min,P<0.001],MMCⅢ期波幅、动力指数、传播速度均比给药前显著升高(P<0.05)。MMC不同时期血浆MOT含量无显著变化(P>0.05),SS水平显著升高(P<0.01),而NO含量显著降低(P<0.05)。结论 5-HT4受体激活对人MMC有兴奋性作用,该兴奋作用可能通过SS、NO等胃肠激素起作用。
Objective To observe the effects of serotonin type 4 （5-HT4） receptor agonist on migrating motor com- plex （MMC） and serum gastroenterological hormones of healthy controls, and explore the impacts of 5-HT4 receptor ag- onist on the MMC and its mechanism in human. Methods Eighteen healthy people were selected, and given the selec- tive 5-HT4 agonist, mosapride. MMC were measured and compared with them before the medicine administrations. Ser- um motilin （MOT）, somatostatin （SS） and nitrogen oxide （NO） concentrations were detected by radio-immunity and nitrate reductase at levels of different MMC stage before and after medicine administrations. Results After healthy con- trois were given selective 5-HT4 receptor agonist, MMC durations were decreased significantly [ （87.5 ± 24.2） min vs （60.5 ± 18.4） rain, P 〈0.001 ）. The contraction amplitudes motility indexes and propagation velocites of MMC phase Ill were increased significantly （P 〈 0.05）. There was no significant difference on serum MOT level of healthy controls in MMC I , Ⅱ , Ⅲ stages （P 〉 0.05） . SS levels of healthy controls in MMC I , Ⅱ , Ⅲ stages were increased signifi- cantly （P 〈 0.01 ）. Plasma NO levels in MMC I , Ⅱ , Ⅲ stages were decreased significantly （P 〈 0.05）. Conclusion 5-HT4 receptor agonist has the excitory effects on MMC of healthy people and it plays the effect through mediating mechanisms of some GI hormones, such as SS and NO.
出处
《胃肠病学和肝病学杂志》
CAS
2014年第3期311-314,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
卫生部临床学科重点项目(2004-54)
