Pokemon在卵巢癌中的表达及临床意义

Expression of pokemon in ovarian cancer and its clinical significance

目的探讨Pokemon蛋白在人卵巢癌组织中的表达及其与临床病理特征之间的关系。方法采用免疫组化法检测50例卵巢癌组织中Pokemon蛋白的表达情况,并分析其与临床病理特征(年龄、临床分期、病理分级和淋巴结转移)的关系。选取同期20例卵巢交界性肿瘤组织和20例正常卵巢组织作对照。结果 Pokemon的阳性表达定位于细胞核和胞质,其在卵巢癌的阳性表达率高于正常卵巢和卵巢交界性肿瘤(P<0.05),而卵巢交界性肿瘤的亦高于正常卵巢(P<0.05);Pokemon阳性表达在不同临床分期、病理分级及淋巴结转移中的差异有统计学意义(P<0.05)。结论 Pokemon在卵巢癌组织中高表达,并与卵巢癌组织分化、临床分期及淋巴结转移有关,对卵巢癌的发生发展有重要作用。

Objective To investigate the expression of pokemon in ovarian caner and its relationship with clinicopathological characteristics. Methods The immunohistochemical method was used to detecte the expression of pokemon in 50 ovarian cancer tis- sues. The relationship between the expression of pokemon and clinicopathological characteristics （age, clinical stage, histological grade and lymph node metastasis） were evaluated in this study. The 20 borderline ovarian tumor tissues and 20 normal ovarian tissues of the same period were chosen as control. Results The positive expression of pokemon was located in the nucleus and cytoplasm. The posi- tive expression rate of ovarian cancer was higher than those of borderline ovarian tumors and normal ovarian with significant difference （P〈O. 05）. There was a higher positive expression rate in borderline ovarian tumor than that in normal ovarian （P〈0.05）. The positive expression rates of pokemon in ovarian cancer statistically varied among different clinical stage, histological grade and lymph node me- tastasis （P〈O. 05）. Conclusion There was a high expression rate of pokemon in ovarian cancer, which was related to clinical stage, lymph metastasis and histological grade. Pokemon plays an important role in occurrence and development of ovarian cancer.