摘要
Tlymphocytes recognize antigen via the heterodimeric T-cell receptor（TCR） which is closely associated with the signal-transducing CD3 complex. αβ TCR-expressing T cells recognize peptides presented by MHC class II （for CD4＋ T cells） or MHC class I molecules （for CD8＋ T cells）. In striking contrast, the majority of human y8 T cells expres- sing the Vy9V82-encoded TCR recog- nize small non-peptidic phosphorylated ligands which have been identified as pyrophosphate intermediates of micro- bial and eukaryotic isoprenoid synthesis.
Tlymphocytes recognize antigen via the heterodimeric T-cell receptor（TCR） which is closely associated with the signal-transducing CD3 complex. αβ TCR-expressing T cells recognize peptides presented by MHC class II （for CD4＋ T cells） or MHC class I molecules （for CD8＋ T cells）. In striking contrast, the majority of human y8 T cells expres- sing the Vy9V82-encoded TCR recog- nize small non-peptidic phosphorylated ligands which have been identified as pyrophosphate intermediates of micro- bial and eukaryotic isoprenoid synthesis.
