摘要
目的运用Meta分析系统评价BNP治疗慢性心力衰竭的远期疗效。方法检索PubMed数据库、MedLine数据库、Embase数据库、Cochrane临床对照试验中心注册库和CNKI全文数据库、万方全文数据库、维普全文数据库自建库以来至2013公开发表的与BNP治疗慢性心力衰竭远期疗效相关的文章。同时，限定文献发表类型为临床随机对照试验。对筛选出的文献查找全文。采用Stata11.0软件对纳入的试验结果进行统计学分析。结果共纳入13篇RCT，共2746名慢性心力衰竭患者，Meta分析结果表明，BNP治疗可以改善慢性心力衰竭患者的全因病死率（OR=0．75，95％CI：0．61-0．92，P=0．007）以及心力衰竭住院率（OR：0．59，95％CI：0．48-0．72，P=0．000）。结论BNP能改善慢性心力衰竭患者的远期预后。
Objective To evaluate the long - term efficacy of BNP or NT - proBNP in the treatment of chronic heart failure patients. Methods PubMed MedLine, Cochrane and China National Knowledge Infrastructure （CNKI） databases were searched for the literatures on the clinical trials of BNP in treatment of chronic heart failure. A meta - analysis was conducted on the outcomes of the included trials with the assistance of Statall. 0 software. Results Totally 13 of the randomized controlled trials （RCT） were discovered including 2746patients with chronic heart failure. BNP can improve all - cause mortality （ OR = 0.75, 95% CI ： 0.61 - 0.92,P = 0. 007 ） and heart fail- ure hospitalization （ OR =0.59,95% CI：0.48 -0.72,P =0.0000） in patients with chronic heart failure. Conclusion BNP can improve long - term prognosis of patients with chronic heart failure.
出处
《医学研究杂志》
2014年第2期89-92,共4页
Journal of Medical Research
