慢性阻塞性肺疾病急性加重期血清脂联素与8-异前列腺素F_(2α)的相关性研究

Association between Serum Adiponectin and 8-Isoprostaglandin F_(2α) in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者血清脂联素（APN）与-异前列腺素F2α（8-iso-PGF2α）水平的变化及相关性。方法收集2012年12月-2013年7月笔者医院呼吸内科住院的AECOPD患者（42例）及正常对照者（42例）血清，采用酶联免疫吸附方法检测血清APN与血清8-isoPGF2α。水平。结果AECOPD患者血清APN与血清8-isoPGF2α明显高于正常对照组，差异有统计学意义（t1=14．51，P〈0．01；t2=17．99，P〈0．01）；AECOPD患者血清APN与血清8-isoPGFα。呈正相关（r=0．80，P〈0．01）。结论AECOPD患者全身炎症反应和氧化应激水平升高，全身炎症反应与氧化应激相关，共同参与COPD的发病机制。

Objective To investigate the association between serum Adiponectin（APN） and 8 - Isoprostaglandin F2~ （8 - iso - PGF2~）in patients with acute exacerbation of chronic obstructive pulmonary disease. Methods ELISA method was used to determine the serum level of APN and 8 -iso -PGF2α in 42 patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） and in 42 control subjects. Results The serum APN and serum 8 - iso - PGF2α levels in patients with AECOPD were higher than those in con- trol subjects （ P 〉 0.01 ）. APN levels were positively correlated with 8 - iso - PGF2α levels in patients（ r = 0.8 ,P 〈 0.01 ）. Conclusion The levels of systemic inflammatory response and oxidative stress were elevated in patients with AECOPD. Systemic inflammatory response is associated with oxidative stress.