期刊文献+

癌症基因组图谱计划数据及分析 被引量:5

Data and analysis of the cancer genome atlas
下载PDF
导出
摘要 人类癌症细胞中通常藏匿着多种引起恶性病变的染色体变异,核酸替换和表观遗传修饰。癌症基因组图谱(the cancer genome atlas,TCGA)计划的目标是获取、刻画并分析人类癌症中大规模、多种变异的分子特征,并且为癌症研究者迅速地提供数据。本文对TCGA数据的四个产生流程以及包含的癌症种类、数据类型、数据水平、分析流程和常用的几种分析工具等进行阐述,同时以卵巢癌(ovarian cancer)为例详细介绍了TCGA数据在突变分析、拷贝数分析、表达分析和通路分析等方面的应用,并对TCGA研究团队近几年有关胶质母细胞瘤(glioblastoma,GBM)的研究方法和结果以及已经完成分析的癌症类型进行综述。 Multiple chromosomal aberrations, nucleotide substitutions, and epigenetic modifications may occur in human cancer cells, which drive malignant transformation. The Cancer Genome Atlas (TCGA) project aims to promote large-scale multi-dimensional analysis of these molecular characteristics in human cancer and rapidly provide data to researchers. In this study, we introduce four flow paths of the production of TCGA data, the collections of various cancer types, the data category and level, and the standardized pipeline of data analysis, as well as several existing data analytical tools. We used ovarian cancer as an example to introduce the application of the TCGA data in the analyses of mutation, copy number, analysis, and expression. We summarized the important findings of glioblasto-ma by TCGA teams.
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2014年第5期349-353,共5页 Chinese Journal of Clinical Oncology
基金 广东省高校引进人才专项资金(编号:YCJ2011-430)资助~~
关键词 癌症基因组图谱 数据类型 数据分析 数据挖掘 cancer genome atlas, data category, data analysis, data mining
  • 相关文献

参考文献26

  • 1Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core path-ways[J].{H}NATURE,2008,(7216):1061-1068.
  • 2Cancer Genome Atlas Research Network. Integrated genomic anal-yses of ovarian carcinoma[J].{H}NATURE,2011,(7353):609-615.
  • 3Cancer Genome Atlas Research Network. Comprehensive molecu-lar characterization of human colon and rectal cancer[J].{H}NATURE,2012,(7407):330-337.
  • 4Beroukhim R,Getz G,Nghiemphu L. Assessing the significance of chromosomal aberrations in cancer:methodology and application to glioma[J].{H}Proceedings of the National Academy of Sciences(USA),2007,(50):20007-20012.
  • 5Cope L,Wu RC,Shih IeM. High level of chromosomal aber-ration in ovarian cancer genome correlates with poor clinical out-come[J].{H}Gynecologic Oncology,2013,(03):500-505.
  • 6Verhaak RG,Hoadley KA,Purdom E. Integrated genomic analysis identifies clinical y relevant subtypes of glioblastoma char-acterized by abnormalities in PDGFRA,IDH1,EGFR,and NF1[J].{H}CANCER CELLS,2010,(01):98-110.
  • 7Noushmehr H,Weisenberger DJ,Diefes K. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma[J].{H}CANCER CELLS,2010,(05):510-522.
  • 8Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous celllung cancers[J].{H}NATURE,2012,(7417):519-525.
  • 9Cancer Genome Atlas Research Network. Comprehensive molecular portraits of human breast tumours[J].{H}NATURE,2012,(7418):61-70.
  • 10Bolton KL,Chenevix-Trench G,Goh C. Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer[J].{H}JAMA:the Journal of the American Medical Association,2012,(04):382-390.

同被引文献62

  • 1薛为民,陆玉昌.文本挖掘技术研究[J].北京联合大学学报,2005,19(4):59-63. 被引量:63
  • 2Snijders C,Matzat U,Reips UD.Big Data':Big gaps of knowledge in the field of Internet[Z].International Journal of Internet Science,2012,7:1-5.
  • 3Yoo C,Ramirez L,Liuzzi J.Big data analysis using modern statistical and machine learning methods in medicine[J].Int Neurourol J,2014,18:50-57.
  • 4Choudhury S,Fishman JR,Mcgowan ML,et al.Big data,open science and the brain:lessons learned from genomics[J].Front Hum Neurosci,2014,8:239.
  • 5Hsieh JC,Li AH,Yang CC.Mobile,cloud,and big data computing:contributions,challenges,and new directions in telecardiology[J].Int J Environ Res Public Health,2013,10:6131-6153.
  • 6Turk-Browne NB.Functional interactions as big data in the human brain[J].Science,2013,342:580-584.
  • 7Koboldt D. The future of cancer genomics [ J ]. Clinical OMICs, 2014,1 (7) :8-10.
  • 8The Cancer Genome Atlas Program Office. Program Overview[ EB/ OL]. [ 2016 -01 - 15 ]. http ://cancergenome. nih. gov/abouttcga/ overview.
  • 9The Cancer Genome Atlas Program Office. How it works[ EB/OL]. [ 2016-01 - 15 ].http ://cancergenome. nih. gov/newsevents/mul- timedialibrary/interactives/howitworks.
  • 10The Cancer Genome Atlas Program (TCGA) :the next stage [ EB/OL] cergenome, nih. gov/newsevents/ Next_Stage. Office. The cancer genome atlas 2016 -01 - 15 ]. http ://can- GA The.

引证文献5

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部