蛋白质组学及代谢组学在酒精性肝病中的应用

Application of proteomics and metabonomics in studies on alcoholic liver disease

酒精性肝病(ALD)是当今全球范围内倍受关注的公共卫生问题之一,其发病机制尚未完全阐明。蛋白质组学和代谢组学为ALD研究开辟了新的途径,且已取得一定进展。全面介绍了蛋白质组学和代谢组学在ALD研究中近10 a的应用现状、存在问题并提出联合蛋白质组学和代谢组学技术应用于ALD研究是一个很好的策略,不仅有助于"全景式"揭示其发病机制,还能为ALD的早期检测、临床诊断、治疗以及预后评估提供重要信息。

Alcoholic liver disease （ALD） has become one of the major public health problems in the world, and its pathogenesis has not yet been completely clarified. Proteomics and metabonomics provide a new way for the studies on ALD, and some progress has been made in this regard. Here, the applications of proteomics and metabonomics in studies on ALD in recent 10 years, as well as existing problems, are com- prehensively reviewed, and it is proposed that joint use of proteomics and metabonomics in studies on ALD is a good strategy, which helps to reveal the pathogenesis of ALD in a panoramic view and provide important information for the early detection, clinical diagnosis, treatment, and prognostic evaluation of ALD.