长期卧床患者应用阿司匹林防治肺栓塞并发症的疗效

Effect of Aspirin in Preventing Complications of Pulmonary Embolism in Bedridden Patients

目的探讨长期卧床患者应用阿司匹林防治肺栓塞并发症的疗效。方法：选择我院2008年10月～2012年10月住院长期卧床患者255例，按数字表达随机分为观察组和对照组。观察组135例，对照组120例，所有患者均根据疾病和病情给予常规药物治疗及一般护理，对照组未给予阿司匹林。观察组在此基础上给予阿司匹林抗凝。记录两组患者12个月内肺栓塞并发症发生率、心脑血管意外发生率、死亡率、并记录观察组药物不良反应发生情况。结果：观察组肺栓塞并发症发生率、死亡率均明显低于对照组，差异有统计学意义（P〈0．05）。结论：长期卧床患者应用阿司匹林能够显著减少肺栓塞并发症，减少心脑血管意外和死亡，值得在临床推广应用。

OBJECTIVE ： To investigate the effect of aspirin in preventing complications of puhnonary embolism in bedridden patients. METHOD： 255 bedridden patients in my hospital from October 2008 to October 2012 were selected and they were divided into control group （120 cases） and experimental group （135 cases） according to a randomized controlled principles. According to disease and illness conventional drug therapy and general care were given in experimental group and the control group did not receive aspi- rin. Based on this observation group accepted aspirin for anticoagulation. Within 12 months the incidence of complications of pulmo- nary embolism, cerebrovascular accident and mortality were recorded. And adverse drug reactions were also recorded in observation group. RESULT： The incidence and the mortality rate of complications of pulmonaiy embolism in observation group was siguificandy lower than that in the control group. There was statistically significant difference （ P 〈 0. 05 ）. CONCLUSION ： Aspirin used in the treatment group can significantly reduce pulmonary complications and cardiovascular and cerebrovascular accident and death in bedridden patients.