哺乳动物雷帕霉素靶蛋白通路激活在Ⅰ期肺腺癌中的意义

Phosphorylation of mammalian target of rapamycin in stage Ⅰ lung adenocarcinoma

目的 探讨哺乳动物雷帕霉素靶蛋白（mTOR）磷酸化代表的mTOR通路激活在Ⅰ期肺腺癌中与临床指标及预后的关系.方法 应用组织微阵列和免疫组织化学方法检测222例Ⅰ期肺腺癌中磷酸化mTOR蛋白,并与临床指标和生存率进行统计学分析.结果 mTOR通路在55％（122/222例）的肺腺癌标本中呈激活状态,其与患者年龄、性别、吸烟史、肿瘤分化等临床指标间无明显相关.生存分析显示,肿瘤中mTOR通路激活的患者预后好（P＜0.05）.结论 mTOR通路的激活是Ⅰ期肺腺癌中的普遍事件,且患者预后较好.

Objective To evaluate the clinical significance of activation of mammalian target of rapamycin （mTOR） pathway,represented by phosphorylation of mTOR protein,in stage Ⅰ lung adenocarcinomas.Methods The activation of mTOR was semi-quantitated in 222 samples of adenocarcinomas by using immunohistochemistry,and its correlation with clinical and survival data was analyzed statistically.Results Activation of mTOR pathway was identified in 55％ （122/222） adenocarcinomas.The activation was not significantly associated with clinical parameters,but patients with mTOR activation had longer survival （P ＜ 0.05）.Conclusion mTOR pathway is frequently activated in stage Ⅰ lung adenocarcinomas and defines a subgroup of patients with a favorable outcome.