利凡诺联合米非司酮配伍米素前列醇腔外引产的临床分析

Clinical analysis of rivanol combined with mifepristone and misoprostol for induced abortion

目的:探讨利凡诺与米非司酮配伍米索前列醇联合用于中期妊娠引产的效果。方法:选取2008~2012年来我单位要求终止妊娠的妇女209例,根据入院时间顺序分为观察组109例与对照组100例。观察组给予米非司酮后行利凡诺腔外引产,同时应用米素前列醇;对照组给予米非司酮后行利凡诺腔外引产。观察两组孕妇的引产效果、胎盘排出时间、腹痛、出血量、宫颈撕裂及不良反应发生情况,并对其进行对比分析。结果:观察组与对照组引产成功率均为100%,观察组胎儿胎盘娩出时间、产程均短于对照组(P<0.05);观察组引产后出血量、腹痛发生率均明显低于对照组;两组对象不良反应发生率无统计学差异。结论:利凡诺联合米非司酮配伍米索前列醇引产能缩短产程、减轻孕妇的痛苦、减少出血量,是一种安全有效的引产方法。

Objective：To explore the clinical effects of rivanol combined with mifepristone and misoprostol for termination of pregnancy. Methods：209 pregnant women required termination between 2008 and 2012 in our hospital were divided into observational group （ n = 109 ） and control group （ n = 100 ） according to sequence on admission. Patients in observational group received rivanol combined with mifepristone and misoprostol, and those in control group were given combined use of rivanol with mifepristone. Two groups were assessed and compared regarding the outcomes of induced labor, placental expulsion time, labor pain in induction, postpartum hemorrhage and incidence of laceration of cervix and other adverse effects~ Results：The two groups went through complete termination of pregnancy. The time of placental expulsion and birth process were shorter, and postpartum bleeding volume, incidence of abdominal pain were significantly lower in the observational group as compare with the control group（ P 〈 0.05 ）, whereas the incidence of adverse effects showed no significant difference for the two groups. Conclusion ： Rivanol combined with either mifepristone or misoprostol or both the latter agent can be safely used for induced abortion in mid-pregnancy with reduced labor pain and less postpartum bleeding besides shortened birth process.