父母过敏史对新生儿脐血细胞因子水平的影响

A study on the influence of parental history of allergy on the level of cytokine in umbilical cord blood

目的探索父母过敏史对新生儿脐血IgE和嗜酸性粒细胞及细胞因子水平的影响,为新生儿脐血细胞因子的筛查、监测及开展过敏性疾病的早期干预提供参考依据。方法以2012年7—12月就诊于义乌市妇幼保健院的136名孕妇为研究对象,采集新生儿脐血样本,检测IgE、嗜酸性粒细胞、IL-13、Eotaxin、IL-9、IL-6、IL-4、IL-5、IFN-γ和IL-10,比较父母均有过敏史组、父母一方有过敏史组和父母无过敏史组3组间的差异。结果 3组人口社会学因素均衡(P>0.05)。3组新生儿脐血细胞因子中位数水平:IL-13(1.82、3.24和6.12 pg/mL)、Eotaxin(29.33、50.71和60.15 pg/mL)、IL-9(43.75、111.17和183.19 pg/mL)、IL6(11.49、19.35和26.09 pg/mL)、IL4(3.67、21.27和49.51 pg/mL)、IL-5(4.26、7.69和10.66 pg/mL)、IFN-γ(338.65、649.17和834.14 pg/mL)、IL-10(7.13、10.56和14.64 pg/mL),差异均有统计学意义(P<0.05)。结论父母的过敏史对新生儿脐血细胞因子水平产生影响,要加强有过敏史父母的新生儿脐血细胞因子的筛查和监测,以利于开展过敏性疾病的早期干预。

Objective To explore the influence of parental history of allergy on the cytokine level of umbilical cord blood of neonates.Methods A prospective study was conducted which selected the pregnant women attending Yiwu maternal and child healthcare hospital from July to December in 2012 as objects.The umbilical cord blood sample were collected to detect the level of IgE,eosinophile granulocyte,eotaxin,IL -9,IL -6,IL -4,IL -5,IFN -γand IL -10. Results A total of 136 subjects were recruited and divided into three groups according to the status of parental allergy histories.There was no significant difference in social and demographic characteristics among the three groups （P＆gt;0.05）. Three groups have significantly different median concentration of IL-13 （1.82pg/mL vs.3.24pg/mL vs.6.12pg/mL）, eotaxin （29.33pg/mL vs.50.71pg/mL vs.60.15pg/mL）,IL-9 （43.75pg/mL vs.111.17pg/mL vs.183.19pg/mL）, IL-6 （11.49pg/mL vs.19.35pg/mL vs.26.09pg/mL）,IL-4 （3.67pg/mL vs.21.27pg/mL vs.49.51pg/mL）,IL-5 （4.26pg/mL vs.7.69pg/mL vs.10.66pg/mL）,IFN-γ（338.65pg/mL vs.649.17pg/mL vs.834.14pg/mL）,IL-10 （7.13pg/mL vs.10.56pg/mL vs.14.64pg/mL）,P 〈0.05.Conclusion Parental history of allergy could have influence on cytokine level of umbilical cord blood.Early screening and surveillance in neonates whose parents have history of allergy should be taken to guide early interventions.