东亚人群绿茶饮用与胃癌发病关系的Meta分析

Green tea consumption and risk of gastric cancer in East Asians: A meta- analysis

目的探讨东亚人群饮用绿茶与胃癌发病的关系。方法以"(茶OR绿茶)AND(胃癌OR胃肿瘤)"的中英文分别检索国内外大型数据库,筛选符合要求的文献,以饮用绿茶与胃癌发病关系的比值比(OR)为统计指标,用STATA11.0软件对各研究数据进行统计分析。结果共纳入10篇文献,其中英文8篇,中文2篇,累计病例4 135例,对照29 512例。Meta分析结果表明:高剂量绿茶摄入组较低剂量绿茶摄入组对胃癌发病的保护作用显著增强[OR=0.75,95%CI(0.64,0.87)];亚组分析显示摄入高剂量绿茶对中国和日本人群中均能减少胃癌发生的风险[中国:OR=0.63,95%CI(0.47,0.84);日本:OR=0.81,95%CI(0.67,0.98)]。结论东亚人群高剂量饮用绿茶对于胃癌发病具有保护作用,仍需大量深入细化的研究来阐明各种相关因素在绿茶降低胃癌发病风险中的作用。

Objective To explore the relationship between green tea cousumption and the risk of gastric cancer in East Asians.Methods All the relevant studies were retrieved and identified .The software STATA11.0 was used for calculating the odds ratio （ OR） .Results A total of 10 studies were recruited ,of which 8 were in English and 2 were in Chinese,involving 4135 gastric cancer cases and 29512 controls.The results of Meta-analysis showed that a higher level of green tea consumption was associated with a reduced risk of gastric cancer [ OR=0.75,95CI0. 64,0.87].Subgroup analysis suggested that a higher level of green tea consumption appears to play a protective role in both Chinese and Japanese [Chinese：OR=0.63,95CI0.47,0.84 ;Japanese：OR=0.81,95CI0.67,0.98].Con-clusions Green tea intake may be involved in the reduction of gastric cancer risk ,but more studies were needed to clarify the effect of relevant factors in the reduction of gastric cancer risk .