老年人群异常血糖波动与动脉硬化关系的研究

The relationship between abnormal fluctuations in abnormal blood glucose level with atherosclerosis in the elderly population people

目的探讨老年人群异常血糖波动与动脉硬化的关系。方法选取血糖异常初诊患者100例,所有患者均予动态血糖监测(CGMS),并行颈动脉血管超声检测。根据颈总动脉内膜中层厚度(CCAIMT)分为2组:CCA-IMT<0.9 mm为正常组(A组,n=52);CCA-IMT≥0.9 mm为增厚组(B组,n=48)。结果①A组患者收缩压、舒张压、体质量指数(BMI)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、平均血糖波动幅度(MAGE)、Ln〔日间血糖平均绝对差(MODD)〕均小于B组,差异有统计学意义(均P<0.05);但两组患者年龄、性别、病程、吸烟史差异无统计学意义(P>0.05)②Logistic回归分析显示:患者SBP高、MAGE高是CCA-IMT增厚的危险因素,OR值分别为1.070、1.479(P<0.05)。结论老年血糖异常人群的日内血糖波动是动脉粥样硬化的独立危险因素之一。

Objective To investigate the relationship between abnormal fluctuations in blood glucose level and atherosclerosis in elderly population Methods A total of 100 newly diagnosed patients with abnormal blood glu-cose were recruited in this study.All patients were assessed by the continuous glucose monitoring system （CGMS） and the ultrasonography were applied for all patients .According to the levels of CCA -IMT,100 patients were classified into 2 groups：the normal group of with CCA -IMT0.05）;（2） Logistic regression showed that incresed level of SBP and MAGEMAGE、SDBG were i-dentified as predictors risk factors for CCA -IMT （with OR 1.070 and 1.479,P〈0.05）.Conclusion Glucose abnormal fluctuations is one of the independently risk factors for atherosclerosis in the elderly people .