钩藤碱对血栓形成及血液流变学影响的实验研究

Experimental Study on Influence of Rhynchophylline on Thrombosis and Blood Rheology

目的:观察钩藤碱对血栓形成及血液流变学影响。方法:将动物随机分为钩藤碱大剂量组(50 mg·kg-1)、中剂量组(35mg·kg-1)、小剂量组(20 mg·kg-1)和空白对照组(等体积生理盐水)。比较各组动物颈动脉完全阻塞时间(血栓形成)、凝血时间、血液流变学指标、血小板聚集性等各项指标。结果:钩藤碱大剂量、中剂量、小剂量3组在延长大鼠颈动脉完全阻塞时间、凝血时间,新西兰兔血液流变学、血小板聚集性方面均优于空白对照组,差异具有统计学意义(P<0.05)。结论:钩藤碱具有抗血栓形成、抗凝血、抗血小板聚集的作用。

Objective：Study on the influence of rhynchophylline on thrombosis and blood rheology. Methods：The animals were randomly divided into the big dose group of rhynchophylline （50mg·kg-1） , in dose group （35 mg·kg-1 ） , small dose group （20 mg·kg-1 ） and the blank group （volumetric saline）. Comparison of the four groups of rats carotid artery completely blocked time （thrombosis） , and clotting time, blood rheology, platelet aggregation index of each index. Results ： The large, medium and small dose group of rhynchophylline in prolonging the rat carotid artery completely blocked time, and clotting time, blood theology, platelet aggregation resistance, blank is better than the control group, a statistically significant （ P 〈 0.05 ）. Conclusions ： The rhynchophylline has the thrombosis, anticoagulant, anti-platelet aggregation function.