摘要
目的:观察加味桃红四物汤治疗腰椎术后血液高凝状态的临床疗效。方法:将83例患者按照随机数字表法分为对照组41例和治疗组42例。对照组术后给予七厘胶囊口服;治疗组术后给予加味桃红四物汤口服。观察术前、术后第1天、第5天、第10天抽血检查凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及D-二聚体(D-D)的变化。结果:两组术后APTT均无明显变化;术后第5天PT均较术前缩短,组间差异无统计学意义(P>0.05);对照组术后10天PT进一步缩短,治疗组变化不明显,组间比较,差异有统计学意义(P<0.05);FIB和D-D与对照组比较,差异有统计学意义(P<0.05);术后10 d治疗组下肢深静脉血栓发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:加味桃红四物汤可有效改善腰椎术后血液高凝状态,降低术后血浆D-D水平,未发现明显不良反应。
Objective:To observe the Modified Taohongsiwutang clinical efficacy of lumbar hypercoagulable state after treatment. Methods :83 patients randomly divided into 42 cases in the control group 41 cases and control groups. The control group was given oral qili capsules;treatment group were given flavored Taohongsiwutang orally. Observed before postoperative day 1, the first five days, the first 10 days blood tests prothrombin time (PT) , activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-dimer( DD ) changes. Results:There were no significant changes in postoperative APTT;former PT than 5 days after surgery to shorten between the two groups was not statistically significant( P 〉 0.05 ) difference ~ the control group after 10 days PT further shorten the treatment group changes ob- vious between the two groups, the difference was statistically significant( P 〈 0.05 ) ;FIB and DD with the control group, the difference was statistically significant( P 〈 0.05 ) ;after 10 d treatment group the incidence of deep venous thrombosis was significantly lower than the control group, the difference was statistically significant ( P 〈 0.05 ). Conclusion : Modified Taohongsiwutang lumbar spine surgery can be effective in improving blood hypercoagulable state, reduce postoperative plasma DD levels and found no significant adverse reactions.
出处
《中医学报》
CAS
2014年第3期427-429,共3页
Acta Chinese Medicine
基金
北京中医药大学自主创新项目(编号:2011-JYB22-JS123)
关键词
加味桃红四物汤
腰椎术
血液高凝状态
下肢深静脉血栓
肺栓塞
七厘胶囊
modified taohongsiwutang
lumbar spine surgery
blood hypercoagulable state
deep vein thrombosis
pulmonary embolism
Qili capsules