摘要
以阿拉伯胶和麦芽糊精为微胶囊壁材，采用喷雾干燥法制备水杨酸微胶囊，并用傅里叶红外光谱及扫描电子显微镜对包埋行为进行鉴定，还研究了最佳阿拉伯胶／麦芽糊精比、微胶囊溶解度、释放机制及体外透皮性，实验结果表明，最佳阿拉伯胶／麦芽糊精比为1：1，微胶囊化后水杨酸溶解度能够提高至26mg/mL。水杨酸微胶囊呈现球状结构，并具有一定的缓释性，体外透皮结果显示微胶囊化后水杨酸透皮速率减慢并且无突释现象，与未包埋水杨酸相比，水杨酸微胶囊具有更高的皮表保留量和较低的皮肤驻留量。
The present work reports on microcapsulation of salicylic acid by spray drying using maltodextrin （MD） , gum arabic （GA） , and encapsulation behavior confirmed by FT-IR and SEM. The optimum GA/MD ratio, solubility, release mechanism and in-vitro transdermal study were evaluated. The results revealed the optimum ratio of 1：1 and an improved water solubility of 26 mg/mL SA microcapsules presented sphere-like structure and a slower release rate than pure SA. In-vitro transdermal results showed that SA microcapsules presented a lower permeability rate within 19 hours with no sudden permeability. Furthermore, SA microcapsules presented higher SA retention on skin surface and lower skin retention.
关键词
水杨酸
微胶囊化
溶解度
释放机制
体外透皮研究
salicylic acid
microcapsulation
solubility
release mechanism
in-vitro transdermal study
