摘要
目的:探讨重复经颅磁刺激(rTMS)结合艾司西酞普兰治疗抑郁症的临床疗效。方法:将68例首发抑郁症患者随机分为对照组和观察组各34例,观察组采用重复经颅磁刺激结合艾司西酞普兰治疗,对照组采用艾司西酞普兰治疗。治疗时间为8周,于8周末评价其疗效,评价指标采用24项汉密顿抑郁量表(HAMD-24)评定。观察各量表评分相对基线值的变化情况。结果:治疗前rTMS结合艾司西酞普兰组HAMD评分[(32.67±6.52)分]与艾司西酞普兰组[(30.88±6.60)分]的差异无统计学意义(t=1.127,P=0.264);治疗第8周末,rTMS结合艾司西酞普兰组23例治愈,8例好转,3例无效;艾司西酞普兰组16例治愈,9例好转,9例无效。两组疗效差异有统计学意义(F=7.843,P=0.005)。治疗后rTMS结合艾司西酞普兰组HAMD评分[(12.20±8.97)分]与艾司西酞普兰组[(19.35±11.43)分]的差异有统计学意义(t=-2.87,P=0.006)。结论:重复经颅磁刺激结合艾司西酞普兰治疗抑郁症患者效果明显,值得临床推广应用。
Objective:To discuss repetitive transcranial magnetic stimulation (rTMS) combined with escitalopram treatment the clinical curative effect of patients depression. Methods: Randomly 68 patients with first-episode depression divided into control group and observation group, the observation group use the rTMS combined with escitalopram ,and the control group adopts escitalopram treatment . After treating 8 W, evaluate its curative effect in 8 weekends, evaluation index with 24 counts of Hamilton depression scale (HAMD - 24). Observe the changes of the rating scale relative to the baseline value. Results:Former rTMS treating combined between escitalopram group of HAMD score [-(32.67±6.52)] and escitalopram group [(30.88±6.60)] had no statistically signifi- cant (t= 1. 127, P=1. 127) ; treated 8 weekends, rTMS combined with escitalopram citalopram group 23 cases were cured, 8 cases were improved, 3 cases ineffective; escitalopram group of 16 cases were cured, 9 cases were improved, 9 cases of invalid. The differ- ence of the two groups had statistically significant (F= 7. 843, P = 0. 005) . After treated the rTMS combined with escitalopram group of HAMD score [-(12. 202±8.97)] and escitalopram group E(19. 35±11. 43)] there difference had statistically significant (t= 2.87,P=0. 006) . Conclusion: The repetitive transcranial magnetic stimulation combined with escitalopram treatment of patients with depression effect is obvious, and worthy of promotion.
出处
《亚太传统医药》
2014年第5期78-79,共2页
Asia-Pacific Traditional Medicine
关键词
艾司西酞普兰
抑郁症
抑郁量表
rTMS
Escitalopram
Depression
Depression Scale