丽水地区艾滋病患者血流感染沙门菌的血清型分布及耐药性分析

Analysis on serotype distribution and resistance of bloodstream infection salmonella for AIDS patients in Lishui

目的分析丽水地区艾滋病患者感染沙门菌的血清型分布和耐药性。方法按国家标准和NCCLS推荐的K-B法对艾滋病标本和体检标本检出的沙门菌进行血清分型和耐药性检测。结果两组标本中检出的沙门菌的菌型分布以B群、C群和D群为主,病人标本检出伤寒沙门菌112株(36.84%),肠炎沙门菌84株(27.63%),德尔卑沙门菌27株(8.88%),其他为阿贡那沙门菌、乙型副伤寒沙门菌、鼠伤寒沙门菌等,体检标本检出沙门菌血清型比较多的是伤寒沙门菌26株(31.71%),肠炎沙门菌17株(20.73%),阿贡那沙门菌6株(7.32%)。药敏试验显示沙门菌敏感性最好的抗生素为氨曲南,对氨苄西林、复方新诺明、左氧氟沙星、环丙沙星、氯霉素的耐药趋势增高,多重耐药比较严重。结论临床医师在选择治疗药物时应参考本地区的菌群、耐药性变化的监测结果,合理正确使用抗菌药物。

Objective To study the serotype distribution and resistance of AIDS patients infection salmonella. Methods Salmonella detected from AIDS sample and health form according to national standard and K-B method recommended by NCCLS received serotype distribution and resistance detection. Results The main bacterial type of serotype distribu- tion detected from two groups of sample,~ included B group,C group and D group. For samples of patients,there were 112 strains of salmonella typhosa（36.84%） ,84 strains of salmonella enteritidis（20.73%） and 27 Salmonella derby （7.32%）. The others were salmonella paratyphi and Salmonella typhimurium. And the serotype of salmonella detected from physi- cal examination specimen included 26 salmonella typhosa （31.71%） and 17 salmonella enteritidis （20.73%）, and 6 Gongna salmonella （7.32%）. The drug sensitive test indicated that antibiotics to which salmonella was most sensitive was aztreonam. And the resistance to ampicillin, selectrin, levofloxacin, Ciprofloxac^n and chloromycetin increased, and the multi-drug resistance was serious. Conclusion While selecting therapeutics, the clinical physician should refer to the local flora and the monitoring results of resistance, and rationally use antibacterial agents.