竹叶消痛颗粒治疗急性痛风性关节炎30例

On 30 Cases of Acute Gouty Arthritis Treated with Zhuye Xiaotong Granule

目的:观察竹叶消痛颗粒治疗急性痛风性关节炎的临床疗效和安全性,为其治疗急性痛风性关节炎提供理论依据。方法:将60例急性痛风性关节炎患者按随机数字表法分为治疗组和对照组,每组30例。治疗组给予竹叶消痛颗粒每次15 g,每日3次,冲服;对照组给予塞来昔布胶囊每次200 g,每日1次,口服。两组均以7 d为1个疗程,疗程结束后观察两组给药前后的症状、体征及红细胞沉降率、C-反应蛋白、血常规、尿常规、ALT、AST、BUN、CR等参数的变化。结果:治疗组能改善急性痛风性关节炎的症状、体征及血清红细胞沉降率、C-反应蛋白等指标(P<0.01),且血、尿常规,ALT,AST,BUN,CR等安全性指标均未见明显改变(P>0.05)。结论:竹叶消痛颗粒治疗急性痛风性关节炎疗效显著,安全性高。

Objective：To observe the clinical efficacy and safety of Zhuye Xiaotong Granule in the treatment of acute gouty arthritis to provide the theoretical basis for the further treatment.Methods：60 cases of acute gouty arthritis were randomly and equally divided into the treatment group and the control group.The treatment group was given Zhuye Xiaotong granule,15 g each time,3 times daily;the control group was given orally Celecoxib Capsules,200 g each time,1 time a day.Their treatment course was 7 days,observing,before and after the treatment,their symptoms,signs,erythrocyte sedimentation rate,C-reactive protein,blood routine,urine routine,ALT,AST,BUN,CR and other parameters.Results：Symptoms,signs,serum erythrocyte sedimentation rate,C-reactive protein and other indicators of the acute gouty arthritis in the treatment group were improved （P＆lt;0.01）,and the blood,urine routine,ALT,AST,BUN,CR and other safety indicators showed no signiifcant change （P＆gt;0.05）.Conclusion：Zhuye Xiaotong Granule has a signiifcant effect and high safety in the treatment of acute gouty arthritis.