游离前列腺特异性抗原、总前列腺特异性抗原联合检测对前列腺疾病的诊断价值

Diagnostic value of combined detection of F-PSA, T-PSA and F-PSA/T-PSA for prostatic diseases

目的探讨血清游离前列腺特异性抗原（F—PSA）、总前列腺特异性抗原（T-PSA）和F—PSA／T-PSA比值在良性前列腺增生和前列腺癌诊断价值。方法选取前列腺疾病患者190例。以化学发光法测定其血清中F-PSA、T-PSA的含量，计算F．PSA／T—PSA比值，并与100例健康体检者进行比较。结果前列腺增生（BPH）患者血清F—PSA、T-PSA含量分别为（1．72±0．87）μg／L、（7．83±6．02）μg/L；前列腺癌（PCa）患者血清F-PSA、T-PSA含量分别为（3．19±1．24）μg／L、（26．34±10．56）μg／L、与健康对照组比较差异均有统计学意义（t’=9．099、14．024，均P〈0．05）。当T-PSA介于4～10μg/L时，BPH、Pca患者血清T—PSA含量分别为（6．44±1．46）μg/L、（7．02±1．72）μg／L，差异无统计学意义（t’=2．118，P〉0．05），但其F．PSA／T-PSA分别为（0．33±0．11）、（0．08±0．07）差异有统计学意义（t’=13．573，P〈0．05）。结论PSA在前列腺疾病的诊断具有较高的价值，联合检测F—PSA、T-PSA以及F／T比值明显优于单项检测PSA。

Objective To explore the clinical value of the levels of serum free prostate specific antigen（ F- PSA） ,total prostate specific antigen（T-PSA） ,the ratio of F-PSA and T-PSA（F-PSA/T-PSA） in the diagnosis of benign prostatic hyperplasia（BPH） and prostate carcinoma （PCa）. Methods The levels of F-PSA, T-PSA and F-PSA ） T-PSA were detected by chemiluminiscent microparticle immunoassay（CMIA） in 190 patients with prostatic diseases and 100 healthy controls, and the ratio of F-PSA to T-PSA was calculated. Results The serum levels of F-PSA and T-PSA were （ 1.72 ±0.87） μg/L and （7.83 ±6.02） μg/L in the patients with BPH. The serum levels of F-PSA and T-PSA were （3.19 ± 1.24）μg/L and （26.34 ± 10.56） μg/L in the patients with PCa. Compared with the healthy controls,the differences were significant （t＇ = 9. 099,14. 024, all P 〈 0.05 ）. As the serum level of T-PSA was 4-10μg/L,the serum contents of T-PSA in BPH patients and PCa patients were （6.44 ± 1.46） μg/L and （7.02 ± 1.72） μg/L, respectively, the difference was not significant between the two groups （ t＇ = 2.118, P 〉 0. 05 ）. However, the F-PSA/T-PSA in BPH patients and PCa patients were （0.33 ± 0.11 ）, （0.08 ± 0.07 ）, respectively. There was significant difference between the two groups （t＇ = 13. 573 ,P 〈 0.05 ）. Conclusion The serum PSA has important value in the diagnosis and differential diagnosis of the patients with prostatic diseases. The combined detection of F- PSA,T-PSA and F-PSA/T-PSA are significantly better than simple detection of PSA in the diagnosis of prostatic diseases.